cigarettes with nicotine more effective than NRT
compared to nicotine replacement therapy (NRT) – up from moderate-certainty in the September 2021 review – and moderate-certainty evidence that they increase quit rates compared to ECs without nicotine. Evidence comparing nicotine EC with usual care/no treatment also suggests benefit, but is less certain. The authors found no difference in adverse events (AEs) between nicotine and
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